Owner Direct Vacation Rentals in Saint Francis Medical Center

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48 Saint Francis Medical Center Vacation Homes From $101

Looking for the ideal vacation rental in Saint Francis Medical Center? Discover an extensive gallery of private rentals offering space, comfort, and authentic local character. Owner Direct simplifies your search by matching you with verified property options.

Updated 3 bedroom unit with balcony!
Updated 3 bedroom unit with balcony!
Apartment
Cape Girardeau, MO, USA
4.0k from Saint Francis Medical Center center

Apartments, Cheap, Accommodations, Parking, Pet-friendly, Lodgings, Vacation rentals, Places to stay

3 Bedrooms6 Guests
8.4

Very Good

6 reviews

$152
Average price / night
Check Availability
Spotless home minutes from everything good Cape Girardeau has to offer
Spotless home minutes from everything good Cape Girardeau has to offer
House
Cape Girardeau, MO, 63703, United States
1.2k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
8.8

Fabulous

3 reviews

$132
Average price / night
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SEMO Redhawks Campus Home with Hot Tub
SEMO Redhawks Campus Home with Hot Tub
House
MO, USA
5.1k from Saint Francis Medical Center center

Cheap, Accommodations, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Jacuzzis, Places to stay

2 Bedrooms4 Guests
10.0

Exceptional

3 reviews

$332
Average price / night
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Relax Here! off Broadway
Relax Here! off Broadway
House
Cape Girardeau, MO, 63701, United States
3.3k from Saint Francis Medical Center center

AC, Balcony, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry

New to Booking
$234
Average price / night
Check Availability
Steps to Southeast Hospital - Fast Wifi - King Bed
Steps to Southeast Hospital - Fast Wifi - King Bed
House
Cape Girardeau, MO, 63701, United States
3.7k from Saint Francis Medical Center center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
10.0

Exceptional

6 reviews

$254
Average price / night
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“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses
“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses
House
Cape Girardeau, MO, 63701, United States
3.8k from Saint Francis Medical Center center

AC, Dryer, Heater, Internet, Laundry, No Smoking, Washer

4 Bedrooms8 Guests
9.8

Exceptional

6 reviews

$216
Average price / night
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Cozy house within walking distance of the historic downtown district.
Cozy house within walking distance of the historic downtown district.
House
Cape Girardeau, MO, 63701, United States
4.0k from Saint Francis Medical Center center

AC, Barbecue, Fireplace, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave

3 Bedrooms5 Guests
9.8

Exceptional

71 reviews

$181
Average price / night
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College town Charm: Minutes from Downtown Cape
College town Charm: Minutes from Downtown Cape
House
Cape Girardeau, MO, 63701, United States
4.0k from Saint Francis Medical Center center

AC, Crib, Dryer, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Laundry

2 Bedrooms6 Guests
10.0

Exceptional

4 reviews

$237
Average price / night
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3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
House
Cape Girardeau, MO, 63701, United States
4.2k from Saint Francis Medical Center center

AC, Barbecue, Dryer, Free Parking, Heater, Internet, Laundry, Living Area, Microwave

3 Bedrooms8 Guests
9.8

Exceptional

23 reviews

$224
Average price / night
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Studio Apt | King Bed, Full Kitchen · By KeenStays
Studio Apt | King Bed, Full Kitchen · By KeenStays
Apartment
Cape Girardeau, MO, 63701, United States
4.2k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

New to Booking
$167
Average price / night
Check Availability
Modern Boho Getaway · 1BR Apartment · By KeenStays
Modern Boho Getaway · 1BR Apartment · By KeenStays
Apartment
Cape Girardeau, MO, 63701, United States
4.3k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

New to Booking
$167
Average price / night
Check Availability
Fresh & Cozy Retreat w/ King Bed · By KeenStays
Fresh & Cozy Retreat w/ King Bed · By KeenStays
Apartment
Cape Girardeau, MO, 63701, United States
4.3k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

1 Bedroom2 Guests
New to Booking
$167
Average price / night
Check Availability
Stay in the \"Gone Girl\" neighborhood
Stay in the \"Gone Girl\" neighborhood
Apartment
cape girardeau, MO, 63701, United States
4.3k from Saint Francis Medical Center center

AC, Barbecue, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave, No Smoking

1 Bedroom2 Guests
9.6

Exceptional

71 reviews

$114
Average price / night
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Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
Downtown 4BR with 2 King Beds! Walking distance to SEMO and the River Front.
Apartment
Cape Girardeau, MO, 63701, United States
4.4k from Saint Francis Medical Center center

AC, Crib, Dryer, Extra Bed, Free Parking, Heater, Internet, Kitchen, Laundry

4 Bedrooms11 Guests
9.0

Fabulous

26 reviews

$251
Average price / night
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Executive Tudor Retreat Near Hospitals & SEMO
Executive Tudor Retreat Near Hospitals & SEMO
House
Cape Girardeau, MO, 63701, United States
4.5k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave, No Smoking

4 Bedrooms6 Guests
New to Booking
$169
Average price / night
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Downtown Cape Getaway with River Views
Downtown Cape Getaway with River Views
Apartment
Cape Girardeau, MO, 63703, United States
4.6k from Saint Francis Medical Center center

AC, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

1 Bedroom2 Guests
10.0

Exceptional

1 reviews

$195
Average price / night
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EN04 - Downtown Private 1BR Apartment in Secure Building
EN04 - Downtown Private 1BR Apartment in Secure Building
Apartment
Cape Girardeau, MO, 63701, United States
4.6k from Saint Francis Medical Center center

AC, Dryer, Elevator, Free Parking, Heater, Internet, Laundry, Microwave, No Smoking

1 Bedroom2 Guests
New to Booking
$122
Average price / night
Check Availability
3-bedroom river view apartment in historic downtown Cape Girardeau
3-bedroom river view apartment in historic downtown Cape Girardeau
Apartment
Cape Girardeau, MO, 63701, United States
4.7k from Saint Francis Medical Center center

3 Bedrooms7 Guests
New to Booking
$111
Average price / night
Check Availability
Corporate Apartment | Fast Wi-Fi | Fenced Parking | Walkable | Riverfront
Corporate Apartment | Fast Wi-Fi | Fenced Parking | Walkable | Riverfront
Apartment
Cape Girardeau, MO, 63703, United States
4.8k from Saint Francis Medical Center center

AC, Fitness Equipment, Free Parking, Heater, Internet, Kitchen, Microwave, No Smoking, TV

1 Bedroom2 Guests
New to Booking
$101
Average price / night
Check Availability
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing Space
House
Cape Girardeau, MO, 63703, United States
4.8k from Saint Francis Medical Center center

AC, Balcony, Fireplace, Free Parking, Heater, Internet, Kitchen, Living Area, Microwave

3 Bedrooms5 Guests
10.0

Exceptional

159 reviews

$246
Average price / night
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Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
House
Cape Girardeau, MO, 63701, United States
4.8k from Saint Francis Medical Center center

AC, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area, Microwave

4 Bedrooms7 Guests
10.0

Exceptional

12 reviews

$270
Average price / night
Check Availability

Pro Tip:
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Frequently Asked Questions

There are a lot of options in Saint Francis Medical Center. If you plan on staying in the Saint Francis Medical Center area, consider making a reservation for a few nights at one of these properties as these have been rated the top Vacation Rentals in Saint Francis Medical Center

You can explore 48 verified vacation rentals in Saint Francis Medical Center. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Saint Francis Medical Center vary depending on the season, property size, and location. Rates typically start from around $101 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Saint Francis Medical Center include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Saint Francis Medical Center welcome pets. Currently, 18 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it's recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Saint Francis Medical Center often include amenities such as Fireplace/Heating, Kitchen, and Bedding/Linens. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.