Owner Direct Vacation Rentals in Lexington Medical Center

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409 Lexington Medical Center Vacation Homes From $78

Looking for the ideal vacation rental in Lexington Medical Center? Discover an extensive gallery of private rentals offering space, comfort, and authentic local character. Owner Direct simplifies your search by matching you with verified property options.

Orange Pit - 3BD 2BA Luxury Retreat - West Cola
Orange Pit - 3BD 2BA Luxury Retreat - West Cola
House
West Columbia, SC, USA
1.7k from Lexington Medical Center center

Air Conditioner, Parking, Internet, Security/Safety, Pet Friendly, Child Friendly

1 Bedroom6 Guests
New to Booking
$350
Average price / night
Check Availability
Keep it simple with this cozy 2-bedroom apartment in welcoming West Columbia.
Keep it simple with this cozy 2-bedroom apartment in welcoming West Columbia.
Apartment
West Columbia, SC, 29169, United States
0.3k from Lexington Medical Center center

AC, Fitness Equipment, Heater, No Smoking

1 Bedroom2 Guests
New to Booking
$78
Average price / night
Check Availability
Mins to USC Hospital Zoo Columbia Duet-Unit B
Mins to USC Hospital Zoo Columbia Duet-Unit B
House
West Columbia, SC, USA
2.9k from Lexington Medical Center center

Pet Friendly, View, Internet, Air Conditioner, Security/Safety, Parking, Fireplace/Heating

1 Bedroom24 Guests
New to Booking
$506
Average price / night
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Poolside Pad - Monthly Stay - Near USC, Lexington, Ft Jackson, I-26 & I-20
Poolside Pad - Monthly Stay - Near USC, Lexington, Ft Jackson, I-26 & I-20
House
West Columbia, SC, 29169, United States
0.6k from Lexington Medical Center center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
New to Booking
$150
Average price / night
Check Availability
Mins to USC Hospital Zoo Columbia Duet-Unit A
Mins to USC Hospital Zoo Columbia Duet-Unit A
House
West Columbia, SC, USA
2.9k from Lexington Medical Center center

Parking, Pet Friendly, Internet, Air Conditioner, Security/Safety, Fireplace/Heating

1 Bedroom18 Guests
New to Booking
$461
Average price / night
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Updated Townhome Close to I20/26
Updated Townhome Close to I20/26
House
West Columbia, SC, 29169, United States
0.6k from Lexington Medical Center center

AC, Barbecue, Dryer, Free Parking, Heater, Hot Tub, Internet, Kitchen, Laundry

3 Bedrooms6 Guests
New to Booking
$136
Average price / night
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Mins to USC, Hospital, Zoo! Columbia Duet- 2 Units
Mins to USC, Hospital, Zoo! Columbia Duet- 2 Units
House
West Columbia, SC, USA
2.9k from Lexington Medical Center center

Parking, Pet Friendly, Internet, Air Conditioner, Security/Safety, Fireplace/Heating

1 Bedroom42 Guests
New to Booking
$1528
Average price / night
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Fully renovated unit beside interstate & hospital!
Fully renovated unit beside interstate & hospital!
Apartment
Lexington County, SC, 29169, United States
0.7k from Lexington Medical Center center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
10.0

Exceptional

1 reviews

$136
Average price / night
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Good Vibes Ranch Pet Friendly
Good Vibes Ranch Pet Friendly
House
West Columbia, SC, USA
3.2k from Lexington Medical Center center

Accommodations, Villas, Vacation homes, Cottages, Pet-friendly, Lodgings, Places to stay

3 Bedrooms6 Guests
New to Booking
$485
Average price / night
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Beside hospital & interstate!
Beside hospital & interstate!
House
Lexington County, SC, 29169, United States
0.7k from Lexington Medical Center center

AC, Dryer, Fireplace, Free Parking, Heater, Internet, Kitchen, Laundry, Living Area

3 Bedrooms6 Guests
New to Booking
$136
Average price / night
Check Availability
15mins to Downtown- Adorable on Taylor Both Units
15mins to Downtown- Adorable on Taylor Both Units
House
West Columbia, SC, USA
4.2k from Lexington Medical Center center

Pet Friendly, View, Internet, Air Conditioner, Security/Safety, Parking, Fireplace/Heating

1 Bedroom18 Guests
New to Booking
$745
Average price / night
Check Availability
1-Story Home | Pets + EV Charger
1-Story Home | Pets + EV Charger
House
West Columbia, SC, 29169, United States
0.8k from Lexington Medical Center center

AC, Dryer, Free Parking, Internet, Kitchen, Living Area, Microwave, No Smoking, TV

3 Bedrooms6 Guests
9.4

Superb

6 reviews

$202
Average price / night
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Sweet Retreat- Mins to Columbia
Sweet Retreat- Mins to Columbia
House
Columbia, SC, USA
4.2k from Lexington Medical Center center

Pet Friendly, View, Internet, Air Conditioner, Security/Safety, Parking, Fireplace/Heating

2 Bedrooms27 Guests
6.0

Review score

2 reviews

$265
Average price / night
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Supersized Tiny House in Rest Haven MH Park
Supersized Tiny House in Rest Haven MH Park
House
West Columbia, SC, 29169, United States
0.8k from Lexington Medical Center center

AC, Balcony, Dryer, Free Parking, Internet, Kitchen, Living Area, Microwave, No Smoking

1 Bedroom4 Guests
New to Booking
$181
Average price / night
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2 Mi to Downtown Columbia Home with Theater Room!
2 Mi to Downtown Columbia Home with Theater Room!
House
West Columbia, SC, USA
4.5k from Lexington Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay

4 Bedrooms9 Guests
New to Booking
$321
Average price / night
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Lovely Patio Home at Lex Med
Lovely Patio Home at Lex Med
House
West Columbia, SC, 29169, United States
0.9k from Lexington Medical Center center

AC, Dryer, Heater, Internet, Laundry, No Smoking, Washer

3 Bedrooms6 Guests
9.8

Exceptional

6 reviews

$260
Average price / night
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Downtown West Cola Home
Downtown West Cola Home
House
West Columbia, SC, USA
4.9k from Lexington Medical Center center

Accommodations, Villas, Vacation homes, Cottages, Lodgings, Places to stay

3 Bedrooms6 Guests
New to Booking
$315
Average price / night
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Comfy 3BR House Near Zoo & I-26
Comfy 3BR House Near Zoo & I-26
House
West Columbia, SC, 29169, United States
1.1k from Lexington Medical Center center

AC, Dryer, Free Parking, Internet, Kitchen, Living Area, Microwave, No Smoking, Toys

3 Bedrooms6 Guests
10.0

Exceptional

1 reviews

$180
Average price / night
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Bungalow - 3BD 2BA - W Cola - Close to Tennis CT
Bungalow - 3BD 2BA - W Cola - Close to Tennis CT
House
West Columbia, SC, USA
5.0k from Lexington Medical Center center

Accommodations, Parking, Villas, Vacation homes, Cottages, Lodgings, Places to stay, Bungalows

1 Bedroom5 Guests
New to Booking
$211
Average price / night
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Cozy Home Close to LMC, UofSC, & Downtown Lexington
Cozy Home Close to LMC, UofSC, & Downtown Lexington
House
West Columbia, SC, 29169, United States
1.1k from Lexington Medical Center center

AC, Dryer, Laundry, Washer

New to Booking
$466
Average price / night
Check Availability
Robin's Nest in WECO w/ Garage & Deck | 4BR 3BR
Robin's Nest in WECO w/ Garage & Deck | 4BR 3BR
House
West Columbia, SC, 29169, United States
1.2k from Lexington Medical Center center

AC, Crib, Dryer, Free Parking, Heater, Internet, Kitchen, Laundry, Microwave

4 Bedrooms8 Guests
10.0

Exceptional

9 reviews

$382
Average price / night
Check Availability

Pro Tip:
OwnerDirectVacationRental aggregates the best inventory from leading travel sites, including Booking.com, Agoda.com, Expedia.com, Vrbo.com, and Airbnb.com. Use our Advanced Filters to compare verified homes, villas, cabins, condos, cottages, vacation rentals, hotels, and eco-friendly stays. Our goal is to help you find the absolute best Vacation Rentals in Lexington Medical Center.

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Frequently Asked Questions

There are a lot of options in Lexington Medical Center. If you plan on staying in the Lexington Medical Center area, consider making a reservation for a few nights at one of these properties as these have been rated the top Vacation Rentals in Lexington Medical Center

You can explore 409 verified vacation rentals in Lexington Medical Center. Our listings are sourced from a range of trusted providers, giving you access to a wide selection of private homes, apartments, and unique stays—all in one place.

Vacation rental prices in Lexington Medical Center vary depending on the season, property size, and location. Rates typically start from around $78 per night, with higher prices for larger homes or peak travel periods. Comparing available options can help you find a stay that matches both your budget and travel plans.

Most vacation rentals in Lexington Medical Center include fully equipped kitchens, making it easy to prepare meals and enjoy a more flexible stay. This is especially useful for families, longer stays, or travelers who prefer a home-like experience.

Yes, many vacation rentals in Lexington Medical Center welcome pets. Currently, 44 listings allow pets, although specific policies may vary by property. You can filter for pet-friendly options to quickly find suitable accommodations.

For popular travel periods such as holidays or peak seasons, it's recommended to book your vacation rental 60 to 90 days in advance to secure the best options. During quieter times, you may still find good availability closer to your travel dates.

Vacation rentals in Lexington Medical Center often include amenities such as Fireplace/Heating, Internet, and Pet Friendly. These features provide added comfort and convenience, making them a popular choice for travelers seeking more space and privacy.

You can use filters to narrow down your search by criteria such as number of bedrooms, guest ratings, or specific amenities like private pools or beachfront access. This makes it easier to find a property that fits your exact needs and preferences.